Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

• DOI: 10.1002/adma.202109764
• Publication Date: 2022-04-07T18:45:14Z
• Authors: Doreen Chan; Jun‐Chau Chien; Eneko Axpe; Louis Blankemeier; Samuel W. Baker; Sarath Swaminathan; Victoria A. Piunova; Dmitry Yu. Zubarev; Caitlin L. Maikawa; Abigail K. Grosskopf; Joseph L. Mann; H. Tom Soh; Eric A. Appel
• Keywords: Biofouling; Polyacrylamide

Biofouling on the surface of implanted medical devices and biosensors severely hinders device functionality drastically shortens lifetime. Poly(ethylene glycol) zwitterionic polymers are currently considered "gold-standard" coatings to reduce biofouling. To discover novel anti-biofouling materials, a combinatorial library polyacrylamide-based copolymer hydrogels is created, their ability screened prevent fouling from serum platelet-rich plasma in high-throughput parallel assay. It found that certain nonintuitive compositions exhibit superior properties over current gold-standard machine learning used identify key molecular features underpinning performance. For validation, surfaces electrochemical coated with performance vitro vivo rodent models evaluated. The preserve function enable continuous measurements small-molecule drug better than coatings. methodology described enables discovery materials can extend lifetime real-time sensing devices.