Tensile‐Strained Palladium Nanosheets for Synthetic Catalytic Therapy and Phototherapy
Neoplasms
0211 other engineering and technologies
Humans
02 engineering and technology
Phototherapy
Catalysis
Palladium
Nanostructures
3. Good health
DOI:
10.1002/adma.202202609
Publication Date:
2022-05-25T04:39:21Z
AUTHORS (8)
ABSTRACT
AbstractPalladium nanosheets (Pd NSs) are well‐investigated photothermal therapy agents, but their catalytic potential for tumor therapy has been underexplored owing to the inactive dominant (111) facets. Herein, lattice tensile strain is introduced by surface reconstruction to activate the inert surface, endowing the strained Pd NSs (SPd NSs) with photodynamic, catalase‐like, and peroxidase‐like properties. Tensile strain promoting the photodynamic and enzyme‐like activities is revealed by density functional theory calculations. Compared with Pd NSs, SPd NSs exhibit lower photothermal effect, but approximately five times higher tumor inhibition rate. This work calls for further study to activate nanomaterials by strain engineering and surface reconstruction for catalytic therapy of tumors.
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