Reversible Deformation of Artificial Cell Colonies Triggered by Actin Polymerization for Muscle Behavior Mimicry

• DOI: 10.1002/adma.202204039
• Publication Date: 2022-06-29T04:04:42Z
• Authors: Chao Li; Xiangxiang Zhang; Boyu Yang; Feng Wei; Yongshuo Ren; Wei Mu; Xiaojun Han
• Keywords: Artificial cell

The use of artificial cells to mimic living tissues is beneficial for understanding the mechanism interaction among cells. Artificial hold immense potential in field tissue engineering. Self-powered capable reversible deformation are developed by encapsulating mitochondria, actins, and methylcellulose. Upon addition pyruvate molecules, mitochondria produce adenosine triphosphate (ATP), which acts as an energy source trigger actin polymerization. occurs with a spindle shape resulting from polymerization actins form filaments adjacent lipid bilayer that subsequently returns spherical depolymerization upon laser irradiation. linear colonies composed these exhibit collective contraction relaxation muscle tissues. At maximum contraction, long axis each giant unilamellar vesicle (GUV) parallel other. All synchronized phase. GUV influenced its GUVs. muscle-like cell described here pave way develop sustainably self-powered