DNA Nanoclusters Combined with One‐Shot Radiotherapy Augment Cancer Immunotherapy Efficiency

Augment Nanoclusters Cancer Immunotherapy
DOI: 10.1002/adma.202208546 Publication Date: 2023-02-06T18:15:18Z
ABSTRACT
Abstract Immunotherapy shows immense promise for improving cancer treatment. Combining immunotherapy with radiotherapy provides a conspicuous advantage due to its enhanced abscopal effect. However, established immune tolerance mechanisms in the tumor microenvironment can hamper generation of sufficient Herein, type DNA nanocluster (DNAnc) that is self‐assembled by CpG‐ODNs‐loaded Y‐shaped double‐stranded vector based on unique complementary base‐pairing rules designed. The structure DNAnc makes it load more than ≈8125.5 ± 822.5 copies CpG ODNs within one single nanostructure, which effectively increases resistance nuclease degradation and elevates efficiency repolarizing macrophages an M1‐like phenotype. Mechanistic studies reveal DNAncs are endocytosed tissue repolarized elicit robust effect accumulation induced radiotherapy, generating potent, long‐term, durable antitumor immunity inhibition metastasis prevention recurrence, novel strategy boost immunotherapy.
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