A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue

• DOI: 10.1002/adma.202208622
• Publication Date: 2022-12-29T11:27:50Z
• Authors: Hufei Wang; Junyao Cheng; Feifei Sun; Xueyu Dou; Jianheng Liu; Yiru Wang; Ming Li; Jianpeng Gao; Xiao Liu; Xing Wang; Fei Yang; Ziran Zhu; Hong Shen; Licheng Zhang; Peifu Tang; Decheng Wu
• Keywords: Hemostatic Agent

Death happening due to massive hemorrhage has been involved in military conflicts, traffic accidents, and surgical injuries of various human disasters. Achieving rapid effective hemostasis save lives is crucial urgent bleeding situations. Herein, a covalent cross-linked AG-PEG glue based on extracellular matrix-like amino-gelatin (AG) PEG derivatives developed. The gelatinizes fast exhibits firm indiscriminate close adhesion with moist tissues upon being dosed. formed establishes an adhesive robust barrier seal the arterial, hepatic, cardiac hemorrhagic wounds, enabling it withstand up 380 mmHg blood pressure comparison normal systolic 60-180 mmHg. Remarkably, from pig penetrating hole 6 mm diameter effectively stopped using within 60 s. Postoperative indexes treated gradually recover wounds regrow significantly at 14 days. Possessing on-demand solubility, self-gelling, degradability, may provide fascinating stop-bleeding approach for clinical emergency rescue.