Rational Design of Platinum–Bismuth Sulfide Schottky Heterostructure for Sonocatalysis‐Mediated Hydrogen Therapy

• DOI: 10.1002/adma.202209589
• Publication Date: 2022-12-18T05:09:41Z
• Authors: Meng Yuan; Shuang Liang; Ling Yang; Fang Li; Bin Liu; Chunzheng Yang; Zhuang Yang; Yulong Bian; Ping'an Ma; Ziyong Cheng; Jun Lin
• Keywords: Sonodynamic therapy; Bismuth

Conventional sonodynamic therapy is unavoidably limited by the tumor microenvironment, although many sonosensitizers have been developed to improve them a certain extent. Given this, concept of sonocatalytic hydrogen evolution proposed, which defined as an oxygen-independent therapeutics. To demonstrate feasibility concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ) selected sonocatalyst and platinum (Pt) nanoparticles are grown in situ optimize their catalytic performance. In this nanocatalytic system, Pt help capture sonoexcited electrons, whereas intratumoral overexpressed glutathione (GSH), natural hole sacrificial agent, can consume holes, greatly improves charge-separation efficiency promotes controllable sustainable H2 generation. Even under hypoxic conditions, Pt-Bi2 also produce sufficient ultrasound irradiation. Mechanistically, mitochondrial dysfunction caused redox homeostasis destruction GSH depletion synergistically damage DNA induce cells apoptosis. At same time, holes trigger decomposition peroxide into O2 relieve hypoxia, thus being synergistic with reverse immunosuppressive microenvironment. The proposed sonocatalysis-mediated will provide new direction realize facile efficient cancer therapy.