Controlled Interfacial Polymer Self‐Assembly Coordinates Ultrahigh Drug Loading and Zero‐Order Release in Particles Prepared under Continuous Flow

• DOI: 10.1002/adma.202211254
• Publication Date: 2023-02-19T10:14:06Z
• Authors: Pei Zhang; Yingxin Liu; Guobing Feng; Cong Li; Jun Zhou; Chunyang Du; Yuancheng Bai; Shuai Hu; Tianhe Huang; Guan Wang; Peng Quan; Jouni Hirvonen; Jin Fan; Hélder A. Santos; Dongfei Liu
• Keywords: Miscibility

Microparticles are successfully engineered through controlled interfacial self-assembly of polymers to harmonize ultrahigh drug loading with zero-order release protein payloads. To address their poor miscibility carrier materials, molecules transformed into nanoparticles, whose surfaces covered polymer molecules. This layer hinders the transfer cargo nanoparticles from oil water, achieving superior encapsulation efficiency (up 99.9%). control payload release, density at oil-water interface is enhanced, forming a compact shell for microparticles. The resultant microparticles can harvest up 49.9% mass fraction proteins kinetics in vivo, enabling an efficient glycemic type 1 diabetes. Moreover, precise engineering process offered continuous flow results high batch-to-batch reproducibility and, ultimately, excellent scale-up feasibility.