Microfluidic Templated Stem Cell Spheroid Microneedles for Diabetic Wound Treatment

• DOI: 10.1002/adma.202301064
• Publication Date: 2023-04-24T17:04:31Z
• Authors: Xiangyi Wu; Danqing Huang; Ye Xu; Guopu Chen; Yuanjin Zhao
• Keywords: Spheroid

Wound dressing patches based on stem cells have demonstrated promising potential in the treatment of diabetic wounds, while their capabilities maintenance cell stemness, effective exchange cellular substance, and precise targeting remain to be promoted. Here, a novel spheroid loaded microneedle (MN@SPs) patch is presented using microfluidic templating technology. By leveraging fluid manipulation template, spheroids (SPs) with uniform size can generated situ. The resulting SPs exhibit advanced viability functions, as evidenced by overexpressed genes related extracellular matrix organization angiogenesis. loading these into microneedles (MNs), platform enables delivery multiple active substances, which contribute neovascularization, collagen deposition, tissue reconstruction wounds. Overall, this microfluidic-engineered therapy demonstrates significant promise promoting wound healing.