Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta2C Modified with Chondroitin Sulfate (TACS)

• DOI: 10.1002/adma.202301585
• Publication Date: 2023-05-24T16:45:11Z
• Authors: Xiangping Song; Qiong Huang; Yuqi Yang; Liang Ma; Wenguang Liu; Chunlin Ou; Qiaohui Chen; Tianjiao Zhao; Zuoxiu Xiao; Mingyuan Wang; Yitian Jiang; Yunrong Yang; Jinping Zhang; Yayun Nan; Wei Wu; Kelong Ai
• Keywords: Intestines; 0301 basic medicine; Oxidative Stress; 0303 health sciences; Chondroitin Sulfates; Humans; Reactive Oxygen Species; Inflammatory Bowel Diseases

Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high expression CD44 receptors. Thanks acid stability, sensitive CT imaging function, strong reactive oxygen species (ROS) elimination ability, oral can accurately locate delineate through non-invasive imaging, specifically treat effectively levels ROS central factor progression As expected, much better therapeutic effects than clinical contrast agent first-line drug 5-aminosalicylic acid, respectively. The mechanism mainly involves protection mitochondria, oxidative stress, inhibiting macrophage M1 polarization, intestinal barrier, restoration flora balance. Collectively, this work provides unprecedented opportunities nanomedicines