Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

• DOI: 10.1002/adma.202310421
• Publication Date: 2024-01-25T12:26:27Z
• Authors: Dingyi Wang; Changyang Xing; Yuan Liang; Chen Wang; Ping Zhao; Xiao Liang; Qiuyang Li; Lijun Yuan
• Keywords: Ultrasound imaging

Vascular microenvironment is found to be closely related immunotherapy efficacy. Identification and ultrasound imaging of the unique vascular characteristics, able predict immune microenvironment, important for decision-making. Herein, it proved that high CD93 expression in tumor vessels poor response prostate cancer. For molecular CD93, CD93-targeted microbubbles (MBs) consist a gaseous core MMRN2 (Multimerin-2) containing cell membrane (CM) /lipid hybrid then synthesized. In vitro vivo assays demonstrate these MBs can recognize efficiently accumulate within regions highly expressing CD93. Contrast-enhanced (CEUS) with demonstrates targeted intensity negatively inflammatory (TIME) cytotoxic T infiltration. Together, endothelial predictor immunosuppressive have great potential evaluate status.