Supramolecular Lipid Nanoparticles Based on Host–Guest Recognition: A New Generation Delivery System of mRNA Vaccines For Cancer Immunotherapy

• DOI: 10.1002/adma.202311574
• Publication Date: 2024-03-04T08:31:52Z
• Authors: Shaolong Qi; Xueyan Zhang; Xinyang Yu; Lulu Jin; Kai Yang; Yangfan Wang; Yunxuan Feng; Jiaqi Lei; Zhengwei Mao; Guocan Yu
• Keywords: Cancer Immunotherapy; Cancer vaccine; Immunopotentiator

Abstract Dendritic cell (DC) maturation is a crucial process for antigen presentation and the initiation of T cell‐mediated immune responses. Toll‐like receptors play pivotal roles in stimulating DC promoting presentation. Here, novel message RNA (mRNA) cancer vaccine reported that boosts antitumor efficacy by codelivering an mRNA encoding tumor TLR7/8 agonist (R848) to using supramolecular lipid nanoparticles (SMLNP) as delivery platform, which new ionizable (N2‐3L) remarkably enhances translation efficiency β‐cyclodextrin (β‐CD)‐modified (Lip‐CD) encapsulates R848. The incorporation R848 adjuvant into through noncovalent host–guest complexation significantly promotes after vaccination, thus resulting superior vivo. Moreover, further boosted synergized with checkpoint blockade potentiating anticancer capability cytotoxic lymphocytes infiltrated sites. This work indicates SMLNP shows brilliant potential next‐generation system development vaccines high efficacy.