Structurally Aligned Multifunctional Neural Probe (SAMP) Using Forest‐Drawn CNT Sheet onto Thermally Drawn Polymer Fiber for Long‐Term In Vivo Operation

• DOI: 10.1002/adma.202313625
• Publication Date: 2024-03-29T22:36:47Z
• Authors: Woojin Jeon; Jae Myeong Lee; Yeji Kim; Yunheum Lee; Joonhee Won; Somin Lee; Wonkyeong Son; Yong Hoe Koo; Ji‐Won Hong; Hocheol Gwac; Jinmyoung Joo; Seon Jeong Kim; Changsoon Choi; Seongjun Park
• Keywords: Biocompatibility; Biological neural network

Abstract Neural probe engineering is a dynamic field, driving innovation in neuroscience and addressing scientific medical demands. Recent advancements involve integrating nanomaterials to improve performance, aiming for sustained vivo functionality. However, challenges persist due size, stiffness, complexity, manufacturing intricacies. To address these issues, neural interface utilizing freestanding CNT‐sheets drawn from CNT‐forests integrated onto thermally functional polymer fibers proposed. This approach yields device with structural alignment, resulting exceptional electrical, mechanical, electrochemical properties while retaining biocompatibility prolonged periods of implantation. Structurally Aligned Multifunctional Probe (SAMP) employing forest‐drawn CNT sheets demonstrates capabilities recording, neurotransmitter detection, brain/spinal cord circuit manipulation via optogenetics, maintaining functionality over year post‐implantation. The straightforward fabrication method's versatility, coupled the device's reliability, underscores significance this technique next‐generation carbon‐based implants. Moreover, longevity multifunctionality position it as promising platform long‐term research.