A Polyplatin with Hands‐Holding Near‐Infrared‐II Fluorophores and Prodrugs at a Precise Ratio for Tracking Drug Fate with Realtime Readout and Treatment Feedback

• DOI: 10.1002/adma.202402452
• Publication Date: 2024-05-01T21:28:52Z
• Authors: Yingjie Yu; Dengshuai Wei; Tiejun Bing; Yongheng Wang; Chaoyong Liu; Haihua Xiao
• Keywords: Tracking (education)

Abstract The in vivo fate of chemotherapeutic drugs plays a vital role understanding the therapeutic outcome, side effects, and mechanism. However, lack imaging abilities drugs, tedious labeling processes, premature leakage agents result loss fidelity between signals. Herein, an amphiphilic polymer is created by copolymerization near‐infrared‐II (NIR‐II) fluorophore tracer (T) anticancer Pt(IV) prodrug (D) cisplatin hand‐holding manner into one chain for first time. obtained Polyplatin DT capable delivering fluorophores concomitantly at precise D/T ratio, thereby resulting tracking platinum even readout them real‐time via NIR‐II imaging. can self‐assemble nanoparticles, referred to as Nanoplatin . Furthermore, caspase‐3 cleavable peptide that serves apoptosis reporter attached , DTR are simultaneously evaluating efficacy. Overall, it reported here design theranostic with drug tracers, efficacy reporters work concert provide insight mechanism action.