Bioinspired Adaptive Microdrugs Enhance the Chemotherapy of Malignant Glioma: Beyond Their Nanodrugs

• DOI: 10.1002/adma.202405165
• Publication Date: 2024-05-17T18:28:51Z
• Authors: Xuejiao Wang; Xiangrong Hao; Yangning Zhang; Qun Wu; Jiajia Zhou; Zhongman Cheng; Jianping Chen; Sijia Liu; Jiahao Pan; Ying Wang; Jun‐Bing Fan
• Keywords: Internalization; Targeted drug delivery; Penetration (warfare)

Solid nanoparticle-mediated drug delivery systems are usually confined to nanoscale due the enhanced permeability and retention effect. However, they remain a great challenge for malignant glioma chemotherapy because of poor efficiency insufficient tumor penetration resulting from blood-brain barrier/blood-brain barrier (BBB/BBTB). Inspired by biological microparticles (e.g., cells) with excellent adaptive deformation, it is demonstrated that microdrugs (even up 3.0 µm in size) more efficient than their nanodrugs (less 200 nm cross BBB/BBTB penetrate into tissues, achieving highly glioma. The distinct mainly attributed interfacial binding endocytosis via deformation. As expected, obtained exhibit accumulation, deep penetration, cellular internalization tissues comparison nanodrugs, significantly improving survival rate glioblastoma mice. It believed bioinspired enable them efficiently physiological barriers deeply delivery, providing an avenue treatment solid tumors.