Tissue/Organ Adaptable Bioelectronic Silk‐Based Implants

• DOI: 10.1002/adma.202405892
• Publication Date: 2024-07-22T09:00:35Z
• Authors: Ziyi Zhu; Zhiwen Yan; Siyuan Ni; Huiran Yang; Yating Xie; Xueying Wang; Dujuan Zou; Chen Tao; Wanqi Jiang; Jianbo Jiang; Zexi Su; Yuxin Xia; Zhitao Zhou; Liuyang Sun; Cunyi Fan; Tiger H. Tao; Xiaoling Wei; Yun Qian; Keyin Liu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Silk; Animals; Biocompatible Materials; Prostheses and Implants; Electrodes, Implanted

AbstractImplantable bioelectronic devices, designed for both monitoring and modulating living organisms, require functional and biological adaptability. Pure silk is innovatively employed, which is known for its excellent biocompatibility, to engineer water‐triggered, geometrically reconfigurable membranes, on which functions can be integrated by Micro Electro Mechanical System (MEMS) techniques and specially functionalized silk. These devices can undergo programmed shape deformations within 10 min once triggered by water, and thus establishing stable bioelectronic interfaces with natively fitted geometries. As a testament to the applicability of this approach, a twining peripheral nerve electrode is designed, fabricated, and rigorously tested, demonstrating its efficacy in nerve modulation while ensuring biocompatibility for successful implantation.