Tissue/Organ Adaptable Bioelectronic Silk‐Based Implants

Biocompatibility Adaptability
DOI: 10.1002/adma.202405892 Publication Date: 2024-07-22T09:00:35Z
ABSTRACT
Abstract Implantable bioelectronic devices, designed for both monitoring and modulating living organisms, require functional biological adaptability. Pure silk is innovatively employed, which known its excellent biocompatibility, to engineer water‐triggered, geometrically reconfigurable membranes, on functions can be integrated by Micro Electro Mechanical System (MEMS) techniques specially functionalized silk. These devices undergo programmed shape deformations within 10 min once triggered water, thus establishing stable interfaces with natively fitted geometries. As a testament the applicability of this approach, twining peripheral nerve electrode designed, fabricated, rigorously tested, demonstrating efficacy in modulation while ensuring biocompatibility successful implantation.
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