Tissue/Organ Adaptable Bioelectronic Silk‐Based Implants

• DOI: 10.1002/adma.202405892
• Publication Date: 2024-07-22T09:00:35Z
• Authors: Ziyi Zhu; Zhiwen Yan; Siyuan Ni; Huiran Yang; Yating Xie; Xueying Wang; Dujuan Zou; Chen Tao; Wanqi Jiang; Jianbo Jiang; Zexi Su; Yuxin Xia; Zhitao Zhou; Liuyang Sun; Cunyi Fan; Tiger H. Tao; Xiaoling Wei; Yun Qian; Keyin Liu
• Keywords: Biocompatibility; Adaptability

Abstract Implantable bioelectronic devices, designed for both monitoring and modulating living organisms, require functional biological adaptability. Pure silk is innovatively employed, which known its excellent biocompatibility, to engineer water‐triggered, geometrically reconfigurable membranes, on functions can be integrated by Micro Electro Mechanical System (MEMS) techniques specially functionalized silk. These devices undergo programmed shape deformations within 10 min once triggered water, thus establishing stable interfaces with natively fitted geometries. As a testament the applicability of this approach, twining peripheral nerve electrode designed, fabricated, rigorously tested, demonstrating efficacy in modulation while ensuring biocompatibility successful implantation.