Photo‐metallo‐immunotherapy: Fabricating Chromium‐Based Nanocomposites to Enhance CAR‐T Cell Infiltration and Cytotoxicity against Solid Tumors

• DOI: 10.1002/adma.202407425
• Publication Date: 2024-06-20T11:35:40Z
• Authors: Qingshuang Zou; Ke Liao; Guangchao Li; Xin Huang; Yongwei Zheng; Gun Yang; Min Luo; Evelyn Y. Xue; Chuanqing Lan; Shuai Wang; Yao Shen; Dixian Luo; Dennis K. P. Ng; Quan Liu
• Keywords: Cancer Immunotherapy; Infiltration (HVAC)

The infiltration and cytotoxicity of chimeric antigen receptor (CAR)-T cells are crucial for effective elimination solid tumors. While metallo-immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR-T cell therapy remains elusive. first single-element nanomaterial based on chromium nanoparticles (Cr NPs) cancer photo-metallo-immunotherapy has been reported previously. Herein, an extended study using biodegradable polydopamine as versatile carrier these nanoparticles, enabling synergistic therapy, reported. results show nanocomposites with or without further encapsulation anticancer drug alpelisib promote migration effect. Upon irradiation near-infrared light, they caused mild hyperthermia "warm" "cold" tumor microenvironment (TME). administration B7-H3 to NOD severe combined immunodeficiency gamma mice bearing human hepatoma PIK3CA-mutated breast significantly inhibit growth after induction by secretion serum cytokines, including IL-2, IFN-γ, TNF-α. trivalent Cr