NIR‐II AIE Liposomes for Boosting Type‐I Photodynamic and Mild‐Temperature Photothermal Therapy in Breast Cancer Treatment

• DOI: 10.1002/adma.202411133
• Publication Date: 2024-11-27T06:08:42Z
• Authors: Shijie Zhen; Zhe Xu; Meng Suo; Teng Zhang; Meng Lyu; Tianwei Li; Tianfu Zhang; Meijing Li; Zujin Zhao; Ben Zhong Tang
• Keywords: Methylene; Methylene blue

Abstract Phototheranositcs has recently aroused extreme attention due to its exceptional advantages. However, the poor photothernostic efficiency, limited penetration depth, strong oxygen‐dependence, and inevitable damage normal tissue of conventional materials severely hindered their total theranostic efficacy. Herein, a series near‐infrared second (NIR‐II) photosensitizers (PSs) featuring aggregation‐induced emission (AIE), NIR‐II fluorescence imaging (FLI), type I photodynamic therapy (PDT) mild‐temperature photothermal (PTT) are constructed through dual‐strategy methods combining donor group engineering fluorination engineering. Profiting from sufficient molecular rotors high electronegativity fluorine, developed 2‐(2‐((5‐(4‐((4‐(diphenylamino)phenyl)(phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (BTS‐2F) 2‐(2‐((5‐(4‐(bis(4‐(diphenylamino)phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (TTS‐2F) endowed with AIE property, radical reactive oxygen species (ROS) generation ability conversion. Through thin film hydration method, prepared BTS‐2F TTS‐2F loaded liposomes exhibit significant FLI improved type‐I PDT/mild‐temperature PTT under laser irradiation both in vitro orthotopic 4T1 mice models.