Implanted Magnetoelectric Bionic Cartilage Hydrogel

• DOI: 10.1002/adma.202415417
• Publication Date: 2025-03-29T00:54:15Z
• Authors: Jiachen Liang; Xinyue Huang; Kaiqi Qin; Hui Wei; Jiaxin Yang; Bin Liu; Zengjie Fan

Enhancing defective cartilage repair by creating a bionic hydrogel supplemented with in situ electromagnetic stimulation, replicating endogenous effects, remains challenging. To achieve this, unique three-phase solvent system is designed to prepare magnetoelectric incorporating piezoelectric poly(3-hydroxybutyric acid-3-hydroxyvaleric acid) (PHBV) and magnetostrictive triiron tetraoxide nanoparticles (Fe3O4 NPs) into sodium alginate (SA) form dual-network, semi-crosslinked chain entanglement structure. The synthesized features similar composition, structure, mechanical properties natural cartilage. In addition, after the implantation of cartilage, motion-driven magnetoelectric-coupled cyclic transformation model triggered gentle joint forces, initiating response that leads transformation. freely excitable cyclically enhanced stimulation it can provide, simulating amplifying obtains induced efficacy superior or magnetic alone.