Nanofibrous Guidance Conduits with Multiple Gradient Cues for Spinal Cord Repair

• DOI: 10.1002/adma.202503892
• Publication Date: 2025-04-29T07:55:32Z
• Authors: Xindan Zhang; Wen Guo; Jiangang Zhang; Feng Xiong; Zehao Yao; Jiaqi Lin; Shuyun Hu; Qingsheng Liu; Feng Tian; Nana Zhao; Yonglai Lu; Jiliang Zhai; Yunfeng Lu; Jiajia Xue
• Keywords: Neural tissue engineering

Abstract Spinal cord injury (SCI) is a debilitating condition that leads to severe disabilities and imposes significant economic social burdens. Current therapeutic strategies primarily focus on symptom management, with limited success in promoting full neurological recovery. In response this challenge, the design of novel guidance conduits incorporating multiple gradient cues, inspired reported by biological processes, enhance spinal repair. These are fabricated using electrospinning masked coaxial electrospraying, simple yet effective method integrates topological, haptotactic, chemotactic cues into single scaffold. The synergy these significantly promoted cell migration, neural stem differentiation neurons, axonal extension, resulting substantial improvements regeneration functional recovery rat model. Single‐nucleus RNA sequencing further demonstrated conduit inhibited fibroblast proliferation, preserved microglial homeostasis, restored cellular proportions, facilitated neuronal axons, dendrites, synapses. This work presents an innovative, versatile platform for fabricating tissue scaffolds integrate offering promising strategy SCI treatment broader applications.