Near‐Infrared Light‐Triggered Intracellular Delivery of Anticancer Drugs Using Porous Silicon Nanoparticles Conjugated with IR820 Dyes

• DOI: 10.1002/admi.201500715
• Publication Date: 2015-12-13T04:25:47Z
• Authors: Bing Xia; Bin Wang; Zhenyu Chen; Qi Zhang; Jisen Shi
• Keywords: Nanocarriers; Biocompatibility; Porous Silicon; Photothermal effect

A near‐infrared (NIR) light‐triggered system based on porous silicon nanoparticles (PSiNPs) conjugated with IR820 dyes is developed for controlled release of doxorubicin hydrocloride (DOX, anticancer drug) inside cancer cells and chemo‐photothermal combination therapy in vitro. PSiNPs are chosen as nanocarriers to encapsulate DOX molecules because their biocompatibility, biodegradability, a high loading capacity effective contents (34.2% ± 6.3%, w/w). Notably, as‐prepared DOX/IR820/PSiNPs nanocomposites also have percentage (98.5%) triggered by NIR light acidic environments, compared that (17.9%) without irradiation under neutral conditions. Furthermore, using localized photostimulation femtosecond laser two‐photo scanning confocal microscope, intracellular from can be dynamically observed situ. Finally, the treatments PSiNPs‐based assessed vitro, which shows synergistic effect including chemotherapy photothermal cells. Therefore, therapeutic approach integrated has great potential light‐stimulated therapy.