Flexible and Transparent Metal Oxide/Metal Grid Hybrid Interfaces for Electrophysiology and Optogenetics

• DOI: 10.1002/admt.202000322
• Publication Date: 2020-06-03T08:49:26Z
• Authors: Zhiyuan Chen; Rose T. Yin; Sofian N. Obaid; Jinbi Tian; Sheena W. Chen; Alana N. Miniovich; Nicolas Boyajian; Igor R. Efimov; Luyao Lu
• Keywords: Indium tin oxide; Bend radius

Abstract Flexible and transparent microelectrodes interconnects provide the unique capability for a wide range of emerging biological applications, including simultaneous optical electrical interrogation systems. For practical biointerfacing, it is important to further improve optical, electrical, electrochemical, mechanical properties conductive materials. Here, high‐performance with high transmittance (59–81%), superior electrochemical impedance (5.4–18.4 Ω cm 2 ), excellent sheet resistance (5.6–14.1 sq −1 using indium tin oxide (ITO) metal grid (MG) hybrid structures are demonstrated. Notably, retain flexible MG other than brittle ITO no changes in even after 5000 bending cycles against small radius at 5 mm. The capabilities ITO/MG highlighted by high‐fidelity recordings transgenic mouse hearts during co‐localized programmed optogenetic stimulation. In vivo histological analysis reveals that fully biocompatible. Those results demonstrate great potential interfaces broad fundamental translational physiological studies.