Neodymium‐Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep‐Tissue Photothermal Therapy

• DOI: 10.1002/adom.201500726
• Publication Date: 2016-03-10T05:06:29Z
• Authors: Blanca del Rosal; Alberto Pérez‐Del...; Elisa Carrasco; Dragana J. Jovanović; Miroslav D. Drami...; Goran Dražić; Ángeles Juarranz ...; Francisco Sanz‐Ro...; Daniel Jaque
• Keywords: Neodymium; Stoichiometry

Nanoparticle‐mediated photothermal therapy (NP‐PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy chemotherapy. The future application of NP‐PTT real life mainly depends on the design synthesis novel multifunctional nanoparticles that could overcome current limitations limited penetration depth absence control. In this work, ultrasmall (≈2.4 nm) NdVO 4 stoichiometric (100% constituent Nd 3+ ions) are reported, which capable vivo sub‐tissue localized heating under 808 nm optical excitation while providing, simultaneously, possibility high near‐infrared fluorescence imaging. Ultrasmall have evidenced superior light‐to‐heat conversion efficiency. This is explained terms their large absorption cross‐section at (consequence particular spectroscopic properties neodymium ions content) well to size leads nonradiative decay rates. Results included work introduce ultrasmall, scientific community agents be considered an alternative traditional systems metallic, organic, carbon‐based nanoparticles.