Asymmetric Aldol Reaction Using Immobilized Proline on Mesoporous Support

• DOI: 10.1002/adsc.200505058
• Publication Date: 2005-08-22T16:18:02Z
• Authors: Félix Calderón; Raquel Fernández; Félix Sánchez; Alfonso Fernández...
• Keywords: Aldol reaction; MCM-41

The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L-proline MCM-41 catalyzed reactions in both hydrophilic hydrophobic solvents, provided stereoselectivities some cases complementary to the homogeneous catalyst. heterogeneous catalysts could be reused without significant lost stereoselectivity.