Novel Enantiocomplementary C2‐Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3,3,3‐Trifluoropyruvate

• DOI: 10.1002/adsc.200800189
• Publication Date: 2008-06-09T08:46:32Z
• Authors: Shuichi Nakamura; Kengo Hyodo; Yuko Nakamura; Norio Shibata; Takeshi Toru
• Keywords: Imidazoline receptor; Friedel–Crafts reaction

Abstract Enantioselective Friedel–Crafts alkylations of a variety indoles with ethyl 3,3,3‐trifluoropyruvate catalyzed by novel chiral m ‐phenylenebis(imidazoline)‐copper(II) complexes or the bis(imidazoline)‐achiral acid combination afforded products high enantioselectivity. Both enantiomers indole derivatives can be prepared enantioselectivities tuning N‐substituents imidazoline.