Manganese Chloride as an Efficient Catalyst for Selective Transformations of Indoles in the Presence of a Keto Carbonyl Group

• DOI: 10.1002/adsc.201100211
• Publication Date: 2011-06-17T20:14:19Z
• Authors: Minghao Li; Jie Yang; Yanlong Gu
• Keywords: Dihydropyran; Acetyl chloride

Abstract Catalysis by manganese chloride tetrahydrate was found to be effective for the selective transformation of indoles, with which desired acid‐catalyzed reaction could promoted and, at same time, a side that also needs assistance acid, electrophilic indole co‐existing keto carbonyl group, does not occur. Some reactions, such as ring‐opening 2‐alkoxy‐3,4‐dihydropyran indole, and transesterification β‐keto ester an alcohol contains C‐3 unsubstituted fragment, performed smoothly using catalyst. A new multicomponent 3,4‐dihydropyran developed catalysis chloride.