A Highly Efficient Tandem Reaction of 2‐(gem‐Dibromovinyl)phenols(thiophenols) with Organosilanes to 2‐Arylbenzofurans (thiophenes)

• DOI: 10.1002/adsc.201100875
• Publication Date: 2012-05-03T12:45:41Z
• Authors: Jie Liu; Wei Chen; Yong Ji; Lei Wang
• Keywords: Silanes; Tandem; Cascade reaction; Ammonium fluoride; Coupling reaction

Abstract 2‐Arylbenzofurans(thiophenes) were prepared through an efficient tandem elimination–intramolecular addition–Hiyama cross‐coupling reaction. In the presence of tetra‐( n ‐butyl)ammonium fluoride (TBAF), palladium(II) acetate [Pd(OAc) 2 ] and triphenylphosphine (PPh 3 ), reaction 2‐( gem ‐dibromovinyl)phenols(thiophenols) with phenyl(trialkoxy)silanes proceeded smoothly generated corresponding products good yields in one‐pot. It should be noted that TBAF plays important role