Copper‐Catalyzed Domino Route to Natural Nostoclides and Analogues: A Total Synthesis of Nostoclides I and II

• DOI: 10.1002/adsc.201300459
• Publication Date: 2013-10-12T02:32:49Z
• Authors: Samuel Inack Ngi; Julien Petrignet; Romain Duwald; El Mostafa El Hilali; Mohamed Abarbri; Alain Duchêne; Jérôme Thibonnet
• Keywords: [SDV] Life Sciences [q-bio]; copper catalysis; heterocyclic compounds; [SDV]Life Sciences [q-bio]; domino reactions; nostoclides; total synthesis; ACIDS; 01 natural sciences; 0104 chemical sciences

AbstractAn original and convenient domino route to natural nostoclides I and II has been developed using a two‐step sequence consisting of a copper‐catalyzed tandem reaction associated with Suzuki cross‐coupling. The methodology employed for this total synthesis appeared to be an interesting and sufficiently flexible tool to allow the synthesis of numerous analogues of these nostoclides.magnified image