Silver‐Catalyzed Decarboxylative Acylarylation of Acrylamides with α‐Oxocarboxylic Acids in Aqueous Media

• DOI: 10.1002/adsc.201300468
• Publication Date: 2013-08-09T10:57:06Z
• Authors: Hua Wang; Li‐Na Guo; Xin‐Hua Duan
• Keywords: Tandem; Aqueous medium; Functional group; Decarboxylation; Reaction conditions

Abstract A mild and efficient silver‐catalyzed acylarylation of activated alkenes with easily available α‐oxocarboxylic acids has been developed. The reactions provide a rapid access to variety functionalized oxindoles via tandem decarboxylative radical cyclization strategy. This transformation proceeds well under reaction conditions exhibits excellent functional group tolerance, affording the desired in good yields. magnified image