Stable Nickel(0) Phosphites as Catalysts for CN Cross‐Coupling Reactions

• DOI: 10.1002/adsc.201400201
• Publication Date: 2014-05-28T19:42:57Z
• Authors: Sven S. Kampmann; Alexandre N. Sobolev; George A. Koutsan...; Scott G. Stewart
• Keywords: Coupling reaction

Abstract Herein we describe the design and preparation of inexpensive, air‐stable nickel phosphite‐based catalysts for use in CN cross‐coupling reaction. The combination tetrakis(triphenyl phosphite) {Ni[P(OPh) 3 ] 4 } 1,1′‐bis(diphenylphosphino)ferrocene (dppf), particular a newly developed catalyst (dppf)Ni[P(OPh) 2 , were found to be extremely effective catalyzing range amination reactions anilines amines with aryl chlorides. This new system offers an alternative bis(cyclooctadienyl)nickel [Ni(COD) palladium(0) commonly used bond formation. magnified image