Room‐Temperature Copper‐Catalyzed Arylation of Dimethylamine and Methylamine in Neat Water

• DOI: 10.1002/adsc.201400785
• Publication Date: 2015-02-04T20:37:08Z
• Authors: Deping Wang; Daizhi Kuang; Fuxing Zhang; Chunlin Yang; Xiaoming Zhu
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractThe first room‐temperature copper‐catalyzed arylations of dimethylamine and methylamine in neat water have been developed. Using a combination of CuI and 6,7‐dihydroquinolin‐8(5 H)‐one oxime as catalyst, dimethylamine is arylated with various aryl halides to give the corresponding products in good to excellent yields. Further, this catalysis enables the selective arylation of methylamine to afford the high yields of monoarylated methylamines as the sole products.magnified image