A Copper‐Benzotriazole‐Based Coordination Polymer Catalyzes the Efficient One‐Pot Synthesis of (N′‐Substituted)‐hydrazo‐4‐aryl‐1,4‐dihydropyridines from Azines

• DOI: 10.1002/adsc.201601072
• Publication Date: 2016-12-21T13:10:30Z
• Authors: Michael Kallitsakis; Edward Loukopoulos; Alaa Abdul‐Sada; Graham J. Tizzard; Simon J. Coles; George E. Kostakis; Ioannis N. Lykakis
• Keywords: Benzotriazole

Abstract A series of new ( N′ ‐substituted)‐hydrazo‐4‐aryl‐1,4‐dihydropyridines was successfully synthesized via a facile one‐pot catalytic pathway utilizing azines and propiolate esters as starting materials one‐dimensional copper benzotriazole‐based coordination polymer catalyst. In the absence catalyst, corresponding 5‐substituted 4,5‐dihydropyrazoles were formed in moderate to high yields. Fine‐tuning catalysts allowed us gain more insights regarding plausible reaction mechanism. magnified image