An Iodine‐Mediated Hofmann‐Löffler‐Freytag Reaction of Sulfoximines Leading to Dihydroisothiazole Oxides

• DOI: 10.1002/adsc.201701178
• Publication Date: 2017-10-02T02:28:43Z
• Authors: Duo Zhang; Han Wang; Hanchao Cheng; José G. Hernández; Carsten Bolm
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractA Hofmann‐Löffler‐Freytag type cyclization reaction of S‐aryl‐S‐phenylpropyl sulfoximines (and related derivatives) was developed. Using molecular iodine as the initiator under visible light a series of five‐membered cyclic products was obtained in moderate to high yields. The approach represents a new strategy for the synthesis of dihydroisothiazole oxides and benzo[d]isothiazoles‐1‐oxides.magnified image