Mechanochemical Cobalt‐Catalyzed C−H Bond Functionalizations by Ball Milling

• DOI: 10.1002/adsc.201800161
• Publication Date: 2018-03-25T10:17:53Z
• Authors: Hanchao Cheng; José G. Hernández; Carsten Bolm
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractBall milling techniques have been applied in the development of a mechanosynthesis of [Cp*Co(CO)I2], which proved highly efficient as catalyst in mechanochemical C−H bond amidations of indoles in a mixer ball mill. A wide range of amidated products is obtained in excellent yields. Compared to the solution‐based methods, the procedure opens a more feasible and environmentally‐friendly access to both the cobalt(III) catalyst and 2‐amidated indoles.magnified image