Organocatalytic Asymmetric Michael Addition of Rhodanines to Azadienes for Assembling of Sulfur‐containing Tetrasubstituted Carbon Stereocenters

• DOI: 10.1002/adsc.201801422
• Publication Date: 2018-11-20T03:26:33Z
• Authors: Wei Lin; Chen Zhang; Wen Xu; Yuyu Cheng; Pengfei Li; Wenjun Li
• Keywords: Stereocenter; Rhodanine; Squaramide; Michael reaction

Abstract The squaramide catalyzed enantioselective Michael addition of rhodanines to 2‐arylidene‐ N ‐tosylbenzofuran‐3(2 H )‐imines has been established, which enables the formation benzofurans bearing both rhodanine and sulfur‐containing tetrasubstituted stereocenter structural motif in good high yields with excellent enantio‐ diastereoselectivities. magnified image