Enamines as Surrogates of Alkyl Carbanions for the Direct Conversion of Secondary Amides to α‐Branched Ketones

• DOI: 10.1002/adsc.201801443
• Publication Date: 2018-12-19T03:05:15Z
• Authors: Yong‐Peng Liu; Shu‐Ren Wang; Ting‐Ting Chen; Cun‐Cun Yu; Ai‐E Wang; Pei‐Qiang Huang
• Keywords: Carbanion

Abstract A direct transformation of secondary amides into α‐branched ketones with enamines as soft alkylation reagents was developed. In this reaction, serve surrogates alkyl carbanions, rather than the conventional enolates equivalents in Stork's reactions, which allowed for easy introduction groups electrophilic functional groups. presence 4 Å molecular sieves, method can be extended to one‐pot coupling aldehydes yield ketones. magnified image