Nickel‐Catalyzed Direct Trifluoroethylation of Aryl Iodides with 1,1,1‐Trifluoro‐2‐Iodoethane via Reductive Coupling

01 natural sciences 0104 chemical sciences
DOI: 10.1002/adsc.202000985 Publication Date: 2020-09-25T02:28:29Z
ABSTRACT
Abstract A nickel‐catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF 3 CH 2 I has been developed, demonstrating high efficiency, excellent functional‐group compatibility, especially large sterically hindered groups. The key to success is the combination nickel readily available nitrogen and phosphine ligands. powerful potential this strategy further demonstrated by late‐stage modification several derived bioactive molecules. magnified image
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (96)
CITATIONS (18)