Nickel‐Catalyzed Direct Trifluoroethylation of Aryl Iodides with 1,1,1‐Trifluoro‐2‐Iodoethane via Reductive Coupling
01 natural sciences
0104 chemical sciences
DOI:
10.1002/adsc.202000985
Publication Date:
2020-09-25T02:28:29Z
AUTHORS (7)
ABSTRACT
Abstract A nickel‐catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF 3 CH 2 I has been developed, demonstrating high efficiency, excellent functional‐group compatibility, especially large sterically hindered groups. The key to success is the combination nickel readily available nitrogen and phosphine ligands. powerful potential this strategy further demonstrated by late‐stage modification several derived bioactive molecules. magnified image
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