Visible‐Light‐Promoted Switchable Synthesis of C‐3‐Functionalized Quinoxalin‐2(1H)‐ones

• DOI: 10.1002/adsc.202001396
• Publication Date: 2021-01-15T18:07:23Z
• Authors: Kim Christopher C...; Boseok Hong; Anna Lee
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractA visible‐light‐promoted synthesis of quinoxalin‐2(1H)‐ones has been developed using 9‐mesityl‐10‐methylacridinium perchlorate as an organo‐photocatalyst. The atmosphere‐controlled method (Ar/air) enabled the selective synthesis of hydroxyl‐ and acyl‐containing quinoxalin‐2(1H)‐ones under mild reaction conditions without the use of any metal catalysts or toxic reagents. A fluorescent labelling experiment showed that hydroxyl‐containing quinoxalin‐2(1H)‐ones may have utility in various biological applications as potent fluorophores.magnified image