Decarboxylation‐Initiated Intermolecular Carbon‐Heteroatom Bond Formation

• DOI: 10.1002/adsc.202100211
• Publication Date: 2021-03-31T02:57:10Z
• Authors: Zhongyi Zeng; Abigail Feceu; Nardana Sivendran; Lukas J. Gooßen
• Keywords: Decarboxylation; Heteroatom; Carboxylate

Abstract Carboxylic acids are among the most used feedstock chemicals due to their great structural diversity and easy handling. The use of carboxylic derivatives in decarboxylative couplings has proven be a valuable tool for construction C−C C‐heteroatom bonds. This synthetic strategy provides complementary bond disconnection traditional cross‐coupling methods. In this review, we provide comprehensive overview decarboxylation‐initiated intermolecular formation, outlining several main mechanistic concepts combined with early examples highlighting achievements made past decade until January 2021. these reactions, undergo initial decarboxylation then react other heteroatom electrophiles nucleophiles, thus replacing carboxylate group prevalent functionality. magnified image