Copper‐Catalyzed Oxidative Carboamination of Maleimides with Amines and α‐Bromo Carboxylates

• DOI: 10.1002/adsc.202200541
• Publication Date: 2022-07-01T03:04:07Z
• Authors: Xueying Zhou; Shanshan Shi; Luya Chen; Ge Wu; Yunfei Ma
• Keywords: Carboxylate

Abstract A copper‐catalyzed oxidative carboamination of maleimides with alkyl amines and α‐bromo carboxylates is described. These multicomponent reactions show good functional group compatibility are suitable for the late‐stage modification a series neuroprotective agents, providing direct path library synthesis 3‐carbo‐4‐amino maleimides. The initial amination to form enamines intermediate, followed by radical alkylation carboxylate compounds, triggers relayed catalytic reaction achieve process. magnified image