Electrochemical Oxidative Carbon‐atom Multifunctionalization and N‐Cyanation of Imine: Synthesis of (Z)‐N′‐Cyano‐N‐carbamimidothioate

• DOI: 10.1002/adsc.202300224
• Publication Date: 2023-04-22T02:38:53Z
• Authors: Xiao Yu; Shengjie Song; Zenghui Zhang; Yi Liu; Mei Zhang; Wenjing Zhu; Guiyun Duan; Pengfei Zhang; Yafei Ji; Chengcai Xia

AbstractCyanoimines (C=N−CN) are eliciting increased attention because of their extensive presence in medicine and biologically active molecules. This study demonstrated the use of the electrochemical oxidative carbon‐atom multifunctionalization and N‐cyanation of imine to synthesize (Z)‐N′‐cyano‐N‐carbamimidothioate. This multicomponent reaction showed good step economy, thereby providing a tool to construct various cyanoimines. Moreover, good functional‐group tolerance and large‐scale synthesis were achieved under metal‐free and external‐oxidant‐free conditions, indicating the potential applicability of this methodology.magnified image