Robust Whole‐Cell‐Based Chemoenzymatic Synthesis of Site‐Selective Deuterated α‐Hydroxy Acids and α‐Amino Acids

• DOI: 10.1002/adsc.202401330
• Publication Date: 2024-10-29T03:35:14Z
• Authors: Keying Yu; Yanqiong Liu; Jingxuan Zhang; Wushuang Zhao; Yingle Mao; Cangsong Liao
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Deuterated hydroxyl acids and amino have been widely utilized in life science, biochemistry drug development. Site‐selective stereoselective synthesis of deuterated remains a significant challenge. Here, we report the development robust whole‐cell‐based chemoenzymatic platform for from off‐the‐shelf aldehydes high yields with excellent selectivities levels deuteration. The delivers products diverse scaffolds deuteration patterns, as well broad scopes both aromatic aliphatic side chains. application was demonstrated by concise deuterium‐containing antiparkinson's disease candidate. This provides concrete foundation accessing acid isotopologs potential applications research discovery