Formal [3+1+1+1] Annulation of 2‐Isocyanophenyl Propargylic Esters and 4‐Hydroxy‐2H‐Chromen‐2‐Ones: An Access to Quinoline‐Fused Polycyclic Skeletons

• DOI: 10.1002/adsc.202401462
• Publication Date: 2025-01-16T03:21:26Z
• Authors: Yu Xing; Xiangheng Li; Zihan Ni; Jiajian Guo; Zijun Zhou; Lei Cui; Chunju Li; Jian Li
• Keywords: Annulation; Quinoline

A cascade reaction involving 2‐isocyanophenyl propargylic ester and 4‐hydroxy‐2H‐chromen‐2‐one has been documented. This leads to the formation of a highly strained cyclopropen‐imine species, thereby offering an efficient route synthesize quinoline‐fused polycyclic skeletons.