Visible Light‐Promoted Cascade Sulfonylation‐Cyclization‐Aromatization of Tertiary Enamides to Access Multi‐Substituted Pyridines and 1,2‐Dihydropyridines

• DOI: 10.1002/adsc.202401516
• Publication Date: 2025-01-28T03:21:48Z
• Authors: Xin‐Ming Xu; Jiping Wang; Sen Chen; Xiaoxu Chen; Jinchun Chen; Qian Liu; Zu‐Li Wang; Miao Tian; Kai Sun
• Keywords: Aromatization; Cascade reaction

Functionalized pyridines and 1,2‐dihydropyridines are crucial organic entities in natural products, materials, drugs catalysts. Despite progress, a facile eco‐friendly synthesis remains desirable so far. In this context, we disclose novel visible light‐promoted radical cascade sulfonylation‐cyclization‐aromatization of N‐propargyl enamides with selenosulfonates. This approach avoids the use metal‐ or photocatalyst, bases external oxidants, marking significant advance sustainable green chemistry accords. Utilizing protocol, successfully synthesized diverse range sulfonated pyridines, featuring good functional group compatibility, simple operation mild condition.