Polymer‐Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis

• DOI: 10.1002/adtp.202100232
• Publication Date: 2022-03-10T03:48:27Z
• Authors: Haoran Liu; Suhong Wu; Hyunho Lee; Gherardo Baudo; Matteo Massaro; Aijun Zhang; Dale J. Hamilton; Elvin Blanco
• Keywords: Macrophage polarization; Bioenergetics; Mitochondrial ROS

Abstract The pro‐inflammatory microenvironment that contributes to atherosclerotic plaque progression is sustained by M1 macrophages. Metabolic reprogramming toward heightened glycolysis accompanies macrophage polarization, with approaches aimed at lessening glycolytic metabolism in macrophages standing impact disease progression. objective decrease the inflammatory response lesions inducing favorable metabolic phenotypes using an innovative mitochondrial transplantation strategy. hypothesis delivery of mitochondria, functionalized a dextran and triphenylphosphonium (Dextran‐TPP) polymer conjugate for enhanced cellular transplantation, plaques properly regulates bioenergetics, attenuating processes preventing Dextran‐TPP mitochondria has profound effects on cell resulting increased oxygen consumption rate reduced flux coincides decreased response. Upon intravenous ApoE −/− mice fed high fat diet, accumulate aortic co‐localize Importantly, treatment reduces burden mice, improving cholesterol levels, ameliorating hepatic steatosis inflammation. Findings highlight as novel biological particle atherosclerosis, underlining potential regulation therapy other diseases.