Functionalized Core–Shell Nanogel Scavenger for Immune Modulation Therapy in Sepsis

• DOI: 10.1002/adtp.202200127
• Publication Date: 2022-07-28T11:30:33Z
• Authors: Xiaotian Ji; Xiguang Yang; Changying Shi; Dandan Guo; Xiaojing Wang; Jennifer M. Messina; Qinghe Meng; Norifumi Urao; Robert N. Cooney; Juntao Luo
• Keywords: Nanogel; Proinflammatory cytokine

Sepsis is a complex, life-threatening hyperinflammatory syndrome associated with organ failure and high mortality due to lack of effective treatment options. Here we report core-shell hydrogel nanoparticle the core functionalized telodendrimer (TD) nanotrap (NT) control hyperinflammation in sepsis. The combination multi-valent charged hydrophobic moieties TD enables binding biomolecules NT. higher crosslinking shell structure nanogel excludes abundant large serum proteins allows for size-selectivity scavenging medium-sized septic molecules (10-30 kDa), e.g., lipopolysaccharides (LPS, potent endotoxin sepsis), thus reducing cytokine production. At same time, NT captures over-flowing proinflammatory cytokines effectively both vitro vivo from biological fluids further hyperinflammation. Intraperitoneal injection attenuates NF-κB activation production LPS-induced mouse models. These results indicate potential applications injectable attenuate local or systemic inflammation.