Mesenchymal Stem Cells‐Derived Extracellular Vesicles in Orthopedic Diseases: Recent Advances and Therapeutic Potential

• DOI: 10.1002/adtp.202300193
• Publication Date: 2023-09-08T01:53:00Z
• Authors: Xinwen Wang; Haodong Tian; Xinquan Yang; Hongmou Zhao; Xiaojun Liang; Yi Li
• Keywords: Regenerative Medicine

Abstract Ever since the first application of mesenchymal stem cell (MSC) transplantation treating human hematologic malignancies in 1995, MSC‐based treatments have demonstrated great therapeutic potential clinical settings. However, only a few therapy products been clinically approved. Accumulating evidence suggests that beneficial effects MSCs are mainly attributed to release paracrine factors or extracellular vesicles (EVs) rather than their mesodermal differentiation potential. Therefore, MSC‐derived EVs (MSC‐EVs), such as exosomes and microvesicles, merged promising alternatives traditional cell‐based therapeutics practice. They offer several advantages better safety, lower immunogenicity, protection cargoes from degradation, ability overcome biological barriers. Moreover, there multiple studies exploring MSC‐EVs for various diseases, including orthopedic disorders. is no definitive “cure” conditions osteoporosis other bone disorders, but displayed significant these ailments. objective this study conduct systematic review current knowledge related emphasize defects, osteoarthritis, osteoporosis, intervertebral disc degeneration, osteosarcoma, osteoradionecrosis.