Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

• DOI: 10.1002/adtp.202400296
• Publication Date: 2024-11-15T09:01:05Z
• Authors: Kaavian Shariati; Meiwand Bedar; Kelly X. Huang; Shahrzad Moghadam; Sarah Mirzaie; Jonnby S. LaGuardia; Wei Chen; Youngnam Kang; Xiaoyan Ren; Justine C. Lee
• Keywords: Biomaterial; Bone remodeling period; Crosstalk

Abstract Tissue regeneration involves dynamic dialogue between and among different cells their surrounding matrices. Bone is specifically governed by reciprocity osteoblasts osteoclasts within the bone microenvironment. Osteoclast‐directed resorption osteoblast‐directed formation of are essential to remodeling, crosstalk these vital curating a sequence events that culminate in creation tissue. Among biomaterial strategies, many have investigated use material cues direct development activity osteoblasts. However, less attention has been given exploring features similarly target osteoclast activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation osteoblast‐osteoclast coupling. This review aims describe various demonstrated influence osteoclastogenesis function, emphasizing those enhance construct's ability achieve healing regeneration. Additionally discussed approaches communication osteoblasts, particularly manner takes advantage Deepening understanding how may dictate differentiation, on microenvironment enable realization bone‐replacement interventions enhanced integrative regenerative capacities.