Nanomicelle‐Assisted Targeted Ocular Delivery with Enhanced Antiinflammatory Efficacy In Vivo

• DOI: 10.1002/advs.201700455
• Publication Date: 2017-11-10T09:49:04Z
• Authors: Yu‐Hua Weng; Xiao‐Wei Ma; Jing Che; Chan Li; Juan Liu; Shi‐Zhu Chen; Yu‐Qin Wang; Ya‐Ling Gan; Hao Chen; Zhong‐Bo Hu; Kai‐Hui Nan; Xing‐Jie Liang
• Keywords: Mucoadhesion; Flurbiprofen

Abstract Ocular inflammations are common diseases that may lead to serious vision‐threatening obstacles. Eye drops for antiinflammation therapy need be administered multiple times daily at a high dosage due the rapid precorneal removal and low bioavailability of drugs. To overcome these problems, cRGD‐functionalized DSPE‐PEG 2000 nanomicelle (DSPE‐PEG ‐cRGD) encapsulated with flurbiprofen is proposed. The tailored nanomicelles trigger specific binding integrin receptors on ocular surface, which leads robust mucoadhesion, superior surface retention, transcorneal penetration behaviors nanomicelles. Due enhanced drug delivery in aqueous humor, functionalized nanoformulation significantly improves efficacy by blocking synthesis inflammatory mediators cytokines. present study demonstrates promising strategy uses functional peptide combined targeted eye ophthalmologic applications.