NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

• DOI: 10.1002/advs.201700782
• Publication Date: 2018-02-07T05:10:51Z
• Authors: Donghui Wang; Naijian Ge; Tingting Yang; Feng Peng; Yuqin Qiao; Qianwen Li; Xuanyong Liu
• Keywords: Layered double hydroxides; Nickel titanium; Crystal (programming language)

Abstract Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), prepared the surface nitinol alloy. The films function as “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation resorb drugs in water when NIR laser shut off. stimuli‐responsive release verified to be related NIR‐triggered crystal phase transformation Au@LDH/B. vitro vivo studies reveal that possess excellent biosafety high efficiency thermochemo therapy, showing application construction drug‐delivery systems.