Screening Small Metabolites from Cells as Multifunctional Coatings Simultaneously Improves Nanomaterial Biocompatibility and Functionality

• DOI: 10.1002/advs.201800341
• Publication Date: 2018-05-24T06:51:54Z
• Authors: Anqi Sun; Zhan Ban; Li Mu; Xiangang Hu
• Keywords: Biocompatibility; Nanomaterials

Abstract Currently, nanomaterials face a dilemma due to their advantageous properties and potential risks human health. Here, strategy improve both nanomaterial biocompatibility functionality is established by screening small metabolites from cells as coatings. A metabolomics analysis of exposed nanosilver (nAg) integrates volcano plots ( t ‐tests fold change analysis), partial least squares‐discriminant (PLS‐DA), significance microarrays (SAM) identifies six l ‐aspartic acid, ‐malic myoinositol, d ‐sorbitol, citric ‐cysteine). The further cell viability, oxidative stress, apoptosis reveals that ‐sorbitol markedly reduces nAg cytotoxicity. Subsequently, molecule loading, surface oxidation, ionic release experiments support the optimal coating for nAg. Importantly, loading improves duration antibacterial activity against Escherichia coli Staphylococcus aureus . biocidal persistence nAg‐sorbitol extended beyond 9 h, effects at 12 h are significantly higher than those naked This work proposes new simultaneously functional coatings, method can be applied mitigate side other nanomaterials.